A hypoxia-inducible factor 1α null splice variant lacking exon 10
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چکیده
منابع مشابه
A hypoxia-inducible factor 1α null splice variant lacking exon 10
Dear Editor, Hypoxia-inducible factor 1 (HIF1) is a master transcription factor that regulates the expression of hypoxia-inducible genes involved in erythropoiesis, vascular remodeling and glucose metabolism in response to hypoxia. Dysregulation of HIF1α has been heavily implicated in tumor progression. In this study, using exome sequencing, we identified a synonymous somatic variant of HIF1α (...
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BACKGROUND Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional regulator of genes regulating oxygen homeostasis. The HIF-1 protein is composed of two HIF-1alpha and HIF-1beta/aryl hydrocarbon receptor nuclear translocator (ARNT) subunits. The prognostic relevance of HIF-1alpha protein overexpression has been shown in breast cancer. The impact of HIF-1alpha alternative splice variant ...
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Cellular response to changes in oxygen tension during normal development or pathologic processes is, in part, regulated by hypoxia-inducible factor (HIF), an oxygen-sensitive transcription factor. HIF activity is primarily controlled through post-translational modifications and stabilization of HIF-1α and HIF-2α proteins and is regulated by a number of cellular pathways involving both oxygen-de...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2017
ISSN: 2041-4889
DOI: 10.1038/cddis.2017.269